Rat VEGF-C (aa 108-223, His Tag) recombinant protein

Cat.#: 503285

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Product Information

  • Product Name
    Rat VEGF-C (aa 108-223, His Tag) recombinant protein
  • Documents
  • Description
    Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.
  • Protein name
    Vascular endothelial growth factor C
  • Uniprot ID
    O35757
  • Gene Name
    Vegfc
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat VEGFC (O35757) (Ala108-Arg223) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat VEGFC comprises 127 amino acids and predicts a molecular mass of 14.5 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Immobilized rat VEGFC-His at 10 μg/mL (100 μL/well) can bind mouse VEGFR3-Fc (cat:502816), The EC50 of mouse VEGFR3-Fc (cat:502816) is 17.4-40.6 ng/mL.
    2. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is 30-150ng/mL.
  • Validations

    Rat VEGFC / VEGF-C Protein (aa 108-223, His Tag) SDS-PAGE

    Rat VEGFC / VEGF-C Protein (aa 108-223, His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"