Rat TL1A / TNFSF15 (Fc Tag) recombinant protein

Rat TL1A / TNFSF15 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

TL1A; VASCULAR ENDOTHELIAL GROWTH INHIBITOR; VEGI192A; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15; VEGI; VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR; TNF LIGAND-RELATED MOLECULE 1; MEMBER 15); TL1; BM20K13.3 (TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY; TNF SUPERFAMILY LIGAND TL1A; VASCULAR ENDOTHELIAL GROWTH INHIBITOR-192A

Q8K3Y7

Human Cells

A DNA sequence encoding the rat TNFSF15 (Q8K3Y7) (Asp94-Ile252) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat TNFSF15/Fc is a disulfide-linked homodimer. The reduced monomer comprises 419 amino acids and has a predicted molecular mass of 46.5 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE