Human TL1A / TNFSF15 (Fc Tag) recombinant protein

Human TL1A / TNFSF15 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

VASCULAR ENDOTHELIAL GROWTH INHIBITOR; TL1A; VEGI192A; TNF SUPERFAMILY LIGAND TL1A; BM20K13.3 (TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY; TL1; TNF LIGAND-RELATED MOLECULE 1; VASCULAR ENDOTHELIAL GROWTH INHIBITOR-192A; VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR; VEGI; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15; MEMBER 15)

O95150

Human Cells

A DNA sequence encoding the human TNFSF15 (NP_005109.2) (Leu72-Leu251) was expressed with the Fc region of human IgG1 at the N-terminus.

Human

The recombinant human TNFSF15 consists of 440 amino acids and predicts a molecular mass of 48.9 kDa.

> 95 % as determined by SDS-PAGE.