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Product Name
Rat OLR1/LOX1 (His Tag) recombinant protein
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Description
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions.
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Protein name
Oxidized low-density lipoprotein receptor 1
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Protein short names
LOX1; CLEC8A; SR-EI; SLOX1; LOX-1; LOXIN; SCARE1
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Uniprot ID
O70156
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Gene Name
Olr1; Lox1; Oldlr1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat OLR1 (O70156) (Leu60-Gln364) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat OLR1 comprises 325 amino acids and has a predicted molecular mass of 37.9 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Rat OLR1 / LOX1 Protein (His Tag) SDS-PAGE
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