Human OLR1/LOX1 (His Tag) recombinant protein

Human OLR1/LOX1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Oxidized low-density lipoprotein receptor 1

LOX1; LOXIN; SCARE1; LOX-1; SLOX1; SR-EI; CLEC8A

P78380

OLR1; CLEC8A; LOX1

Human Cells

A DNA sequence encoding the human OLR1 (P78380) extracellular domain (Ser 61-Gln 273) was expressed, with a polyhistidine tag at the N-terminus.

Human

The recombinant human OLR1 consists of 229 amino acids and has a calculated molecular mass of 26.5 kDa. It exists as a disulfide-linked homodimer. As a result of glycosylation, the apparent molecular mass of rhOLR1 is approximately 30-35 kDa in SDS-PAGE under reducing conditions, and 60-70 kDa in non-reduced SDS-PAGE.

> 85 % as determined by SDS-PAGE