Rat OLR1/LOX1 (Fc Tag) recombinant protein

Rat OLR1/LOX1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Oxidized low-density lipoprotein receptor 1

SCARE1; LOXIN; LOX-1; SLOX1; SR-EI; CLEC8A; LOX1

O70156

Olr1; Lox1; Oldlr1

Human Cells

A DNA sequence encoding the rat OLR1 (O70156) (Leu60-Gln364) was expressed with Fc region of human IgG1 at the N-terminus.

Rat

The recombinant rat OLR1 comprises 565 amino acids and predicts a molecular mass of 63.9 kDa. The apparent molecular mass of the recombinant protein is approximately 66 and 35 kDa in SDS-PAGE under reducing conditions due to glycosylation.

(90.4+8.5) % as determined by SDS-PAGE