Rat interleukin-20 recombinant protein

Rat interleukin-20 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.It has been shown that interleukin-20 transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Galectin-1

ZCYTO10; CYTOKINE ZCYTO10; FOUR ALPHA HELIX CYTOKINE; MGC96907; MGC130536; UNQ852/PRO1801; FOUR ALPHA HELIX CYTOKINE ZCYTO10; IL10D; FOUR HELIX BUNDLE CYTOKINE 10; IL-20; INTERLEUKIN-20

P11762

Lgals1

E. coli

A DNA sequence encoding the rat IL20 (P11762) (Leu25-Leu176) was expressed and purified.

Rat

The recombinant rat IL20 consists of 153 amino acids and has a predicted molecular mass of 17.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 17 kDa in SDS-PAGE under reducing conditions.

> 85 % as determined by SDS-PAGE