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Product Name
Rat IL-4R/CD124 (His Tag) recombinant protein
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Description
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a type? transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
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Protein name
Interleukin-4 receptor subunit alpha
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Protein short names
IL4RA; MGC118473; CD124; IL4R
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Uniprot ID
Q63257
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Gene Name
Il4r; Il4ra
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat IL4R (Q63257-1) (Met1-Arg232) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat IL4R comprises 218 amino acids and predicts a molecular mass of 25.3 kDa.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind biotinylated mouse IL4-His (Cat:502101) in a functional ELISA.
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Validations
Rat IL4R / Il4ra Protein (His Tag) SDS-PAGE
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