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Rat IL-4R/CD124 (Fc Tag) recombinant protein

Cat.#: 502616

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Product Information

  • Product Name
    Rat IL-4R/CD124 (Fc Tag) recombinant protein
  • Documents
  • Description
    Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).
  • Protein name
    Interleukin-4 receptor subunit alpha
  • Protein short names
    IL4RA; MGC118473; CD124; IL4R
  • Uniprot ID
    Q63257
  • Gene Name
    Il4r; Il4ra
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat IL4R (Q63257-1) (Met1-Arg232) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat IL4R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 448 amino acids and has a predicted molecular mass of 50.9 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized mouse IL4-His (Cat:502101) at 10 μg/mL (100 μl/well) can bind rat IL4R-Fc (Cat:502616), The EC50 of rat IL4R-Fc (Cat:502616) is 0.12-0.29 μg/mL.
  • Validations

    Rat IL4R / Il4ra Protein (Fc Tag) SDS-PAGE

    Rat IL4R / Il4ra Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"