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Product Name
Rat IFN-alpha / IFNA1 / IFN (Fc Tag) recombinant protein
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Description
IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs can activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they also increase the ability of uninfected host cells to resist new infection by virus.Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon is produced by mitogen- or antigen-stimulated T lymphocytes. IFNA1 is produced by macrophages and has antiviral activities.
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Protein name
Interferon alpha-1
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Protein short names
IFN; IFN-ALPHAD; MGC138505; IFN-ALPHA-1; LEIF D; INTERFERON ALPHA-1/13; IFN-ALPHA 1B; INTERFERON ALPHA 1B; MGC138207; IFA1; MGC138507; INTERFERON-ALPHA1; IFNA13; INTERFERON ALPHA-D; IFNA ; INTERFERON ALPHA-1; IFL; RP23-360M23.1; IFN-ALPHA-1/13; IFN-ALPHA; INTERFERON ALPHA FAMILY GENE 1
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Uniprot ID
P05011
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Gene Name
Ifna1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat IFNA1 (P05011) (Met 1-Ser 192) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat IFNA1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 410 amino acids and predicts a molecular mass of 46.4 kDa. The apparent molecular mass of the rat IFNA1/Fc monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is 1-10 μg/mL. -
Validations
Rat IFN-alpha / IFNA1 / IFN Protein (Fc Tag) SDS-PAGE
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