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RAD51 antibody

Cat.#: 114515

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Product Information

  • Product Name
    RAD51 antibody
  • Documents
  • Description
    RAD51 Rabbit Polyclonal antibody. Positive IP detected in mouse testis tissue. Positive WB detected in mouse testis tissue, HeLa cells. Observed molecular weight by Western-blot: 37kd
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    BRCC5 antibody; HRAD51 antibody; HsRad51 antibody; HsT16930 antibody; RAD51 antibody; RAD51 homolog A antibody; RAD51A antibody; RECA antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RAD51 recombinant protein (Accession Number: BC001459). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

  • Validations

    mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:114515(RAD51 Antibody) at dilution of 1:1000

    mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:114515(RAD51 Antibody) at dilution of 1:1000

    IP Result of anti-RAD51 (IP:Catalog No:114515, 3ug; Detection:Catalog No:114515 1:1000) with mouse testis tissue lysate 4000ug.

    IP Result of anti-RAD51 (IP:Catalog No:114515, 3ug; Detection:Catalog No:114515 1:1000) with mouse testis tissue lysate 4000ug.

  • Background
    RAD51 plays a critical role in the maintenance of genomic integrity by functioning in the repair of DNA double-strand breaks. It mediates homologous pairing and strand exchange in recombinatory structures known as RAD51foci in the nucleus. It also can bind to single and double stranded DNA and exhibits DNA-dependent ATPase activity. In addition, it has a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
  • References
    • Groselj B, Kerr M, Kiltie AE. Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 108(3):429-33. 2013.
    • Jiang W, Li YQ, Liu N. 5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation. PloS one. 9(4):e93273. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"