RAD23A antibody

RAD23A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RAD23A Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive IP detected in Jurkat cells. Positive WB detected in Jurkat cells, mouse spleen tissue, rat spleen tissue. Observed molecular weight by Western-blot: 55kd

ELISA, WB, IHC, IP

Human, Mouse, Rat; other species not tested.

HHR23A antibody; HR23A antibody; RAD23A antibody

Rabbit IgG

This antibody was obtained by immunization of RAD23A recombinant protein (Accession Number: NM_005053). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RAD23A, also named as HHR23A, belongs to the RAD23 family. It is a multiubiquitin chain receptor involved in modulation of proteasomal degradation. RAD23A binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. It is proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. It is involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. It is also involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages and is required for the association of HIV-1 vpr with the host proteasome. This antibody is a rabbit polyclonal antibody raised against a fusion protein of full length human RAD23A.

• Laço MN, Cortes L, Travis SM, Paulson HL, Rego AC. Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. PloS one. 7(9):e43563. 2012.