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Product Name
RAB3GAP2 antibody
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Description
RAB3GAP2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IHC detected in human brain tissue, human cerebellum tissue. Observed molecular weight by Western-blot: 110 / 130 / 150 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse, Rat; other species not tested.
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Alternative names
DKFZp434D245 antibody; FLJ14579 antibody; KIAA0839 antibody; p150 antibody; Rab3 GAP p150 antibody; Rab3 GAP regulatory subunit antibody; RAB3 GAP150 antibody; RAB3GAP150 antibody; RAB3GAP2 antibody; RGAP iso antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RAB3GAP2 recombinant protein (Accession Number: NM_012414). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114446(RAB3GAP2 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human brain tissue slide using Catalog No:114446(RAB3GAP2 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human brain tissue slide using Catalog No:114446(RAB3GAP2 Antibody) at dilution of 1:50 (under 40x lens)
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Background
RAB3GAP2, also known as RAB3-GAP150, belongs to the Rab3-GAP regulatory subunit family. Rab3 GAP consists of two subunits: the catalytic subunit p130 and the noncatalytic subunit p150. Rab3 GAP is ubiquitously expressed and enriched in the synaptic soluble fraction of brain, consistent with it having a key role in neurodevelopment. RAB3-GAP150 forms the Rab3 GTPase-activating complex with RAB3-GAP130,where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. Defects in RAB3-GAP150 are the cause of Martsolf and Warburg Micro syndrome.
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