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Product Name
Mouse FTLS / RSPO2 (Fc Tag) recombinant protein
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Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.
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Protein name
R-spondin-2
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Protein short names
ROOF PLATE-SPECIFIC SPONDIN-2; UNQ9384/PRO34209; R-SPONDIN 2 HOMOLOG; R-SPONDIN-2; FTLS; D430027K22; CRISTIN2; AA673245; 2610028F08RIK
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Uniprot ID
Q8BFU0
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Gene Name
Rspo2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Rspo2 (NP_766403.1) (Met1-Gly205) was expressed with the Fc region of mouse IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Rspo2 consists 416 amino acids and predicts a molecular mass of 47.4 kDa.
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Purity
> 85 % as determined by SDS-PAGE.
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Validations
Mouse R-Spondin 2 / FTLS / RSPO2 Protein (Fc Tag) SDS-PAGE
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