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Product Name
QKI antibody
- Documents
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Description
QKI Rabbit Polyclonal antibody. Positive WB detected in K-562 cells. Positive IP detected in K-562 cells. Observed molecular weight by Western-blot: 38kd
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp586I0923 antibody; HKQ antibody; Hqk antibody; HqkI antibody; Protein quaking antibody; QK1 antibody; QK3 antibody; QKI antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of QKI recombinant protein (Accession Number: NM_006775). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:114367(QKI antibody) at dilution of 1:400
IP Result of anti-QKI (IP:Catalog No:114367, 4ug; Detection:Catalog No:114367 1:400) with K-562 cells lysate 3600ug.
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Background
QKI belongs to a family of RNA-binding proteins, which have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. It involves in regulation of RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability. Also it required to protect and promote stability of mRNAs such as MBP and CDKN1B. Beside, it acts as a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"