-
Product Name
PTPN22 antibody
- Documents
-
Description
PTPN22 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Positive IP detected in Jurkat cells. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 79-95 kDa
-
Tested applications
ELISA, WB, IHC, IP
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
Lymphoid phosphatase antibody; LYP antibody; LYP1 antibody; LYP2 antibody; PEP antibody; PTPN22 antibody; PTPN8 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of PTPN22 recombinant protein (Accession Number: BC017785). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
-
Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:114319(PTPN22 antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:114319(PTPN22 antibody) at dilution of 1:50 (under 10x lens)
IP Result of anti-PTPN22 (IP:Catalog No:114319, 4ug; Detection:Catalog No:114319 1:300) with Jurkat cells lysate 3080ug.
-
Background
PTPN22(Tyrosine-protein phosphatase non-receptor type 22) is also named as LyP,PEP,PTPN8.It belongs to the protein-tyrosine phosphatase family and non-receptor class 4 subfamily.It acts as negative regulator of T-cell receptor (TCR) signaling.Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE).It has 5 isoforms produced by alternative splicing.
-
References
- Varga A, Jenes A, Marczylo TH. Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons. Pflügers Archiv : European journal of physiology. 466(7):1421-35. 2014.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"