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Product Name
PTPN2 antibody
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Description
PTPN2 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in mouse thymus tissue, HeLa cells, HL-60 cells, NIH/3T3 cells. Positive IP detected in HL-60 cells. Observed molecular weight by Western-blot: 49 kDa, 45 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
PTPN2 antibody; PTPT antibody; TC PTP antibody; TCELLPTP antibody; TCPTP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PTPN2 recombinant protein (Accession Number: NM_080423). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:114318(PTPN2 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:114318(PTPN2 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-PTPN2 (IP:Catalog No:114318, 4ug; Detection:Catalog No:114318 1:500) with HL-60 cells lysate 4000ug.
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Background
PTPN2(Tyrosine-protein phosphatase non-receptor type 2) is also named as PTPT and belongs to the protein-tyrosine phosphatase family. It may modulate beta-cell apoptosis and/or local release of inflammatory mediators in the course of a viral infection by acting, at least in part, at the pancreatic beta-cell level(PMID: 19825843). This protein has 3 isoforms produced by alternative splicing.
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References
- Wakeel A, Kuriakose JA, McBride JW. An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. Infection and immunity. 77(5):1734-45. 2009.
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