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  • PTHLH Polyclonal Antibody
  • PTHLH Polyclonal Antibody
  • PTHLH Polyclonal Antibody

PTHLH Polyclonal Antibody

Cat.#: 163244

Special Price 174.2 USD

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Product Information

  • Product Name
    PTHLH Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to PTHLH
  • Tested applications
    IHC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    PTHLH antibody; BDE2 antibody; HHM antibody; PLP antibody; PTHR antibody; PTHRP antibody; parathyroid hormone like hormone antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-175 of human PTHLH (NP_945315.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IHC 1:50 - 1:200
  • Validations

    Immunohistochemistry - PTHLH Polyclonal Antibody

    Immunohistochemistry - PTHLH Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat brain using PTHLH antibody at dilution of 1:200 (40x lens).

    Immunohistochemistry - PTHLH Polyclonal Antibody

    Immunohistochemistry - PTHLH Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded mouse brain using PTHLH antibody at dilution of 1:200 (40x lens).

    Immunohistochemistry - PTHLH Polyclonal Antibody

    Immunohistochemistry - PTHLH Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human gastric cancer using PTHLH antibody at dilution of 1:200 (40x lens).

  • Background
    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.; Osteostatin is a potent inhibitor of osteoclastic bone resorption.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"