Rat GITR / TNFRSF18 (Fc Tag) recombinant protein

Cat.#: 502822

Size:

Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Rat GITR / TNFRSF18 (Fc Tag) recombinant protein
  • Documents
  • Description
    GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
  • Protein name
    Protein Tnfrsf18
  • Protein short names
    GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN; RP5-902P8.2; CD357; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18; AITR; RP23-118E21.6; GITR; ACTIVATION-INDUCIBLE TNFR FAMILY RECEPTOR; GITR-D; TNF RECEPTOR SUPERFAMILY ACTIVATION-INDUCIBLE PROTEIN
  • Uniprot ID
    Q5M835
  • Gene Name
    Tnfrsf18; LOC500598
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat TNFRSF18/Fc is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a predicted molecular mass of 37.7 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Rat GITR / TNFRSF18 Protein (Fc Tag) SDS-PAGE

    Rat GITR / TNFRSF18 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"