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Product Name
Rat GITR / TNFRSF18 (Fc Tag) recombinant protein
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Description
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
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Protein name
Protein Tnfrsf18
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Protein short names
GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN; RP5-902P8.2; CD357; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18; AITR; RP23-118E21.6; GITR; ACTIVATION-INDUCIBLE TNFR FAMILY RECEPTOR; GITR-D; TNF RECEPTOR SUPERFAMILY ACTIVATION-INDUCIBLE PROTEIN
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Uniprot ID
Q5M835
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Gene Name
Tnfrsf18; LOC500598
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat TNFRSF18/Fc is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a predicted molecular mass of 37.7 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Rat GITR / TNFRSF18 Protein (Fc Tag) SDS-PAGE
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