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Product Name
Human GITR / TNFRSF18 (His Tag) recombinant protein
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Description
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
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Protein name
Tumor necrosis factor receptor superfamily member 18
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Protein short names
GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18; AITR; GITR; RP23-118E21.6; CD357; RP5-902P8.2; ACTIVATION-INDUCIBLE TNFR FAMILY RECEPTOR; TNF RECEPTOR SUPERFAMILY ACTIVATION-INDUCIBLE PROTEIN; GITR-D
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Uniprot ID
Q9Y5U5
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Gene Name
TNFRSF18; AITR; GITR; UNQ319/PRO364
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human TNFRSF18 (NP_683700.1) (Met1-Glu161) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human TNFRSF18 consists 147 amino acids and predicts a molecular mass of 16 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Human GITR / TNFRSF18 Protein (His Tag)
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