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Product Name
Human PSME3 / PA28-gamma (His Tag) recombinant protein
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Description
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Interacts with human cytomegalovirus UL27.
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Protein name
Proteasome activator complex subunit 3
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Protein short names
REGGAMMA; MACROPAIN) ACTIVATOR SUBUNIT 3 (PA28 GAMMA; KI ANTIGEN; KI NUCLEAR AUTOANTIGEN; KI; PA28G; HEL-S-283; PROTEASOME (PROSOME; MACROPAIN) 28 SUBUNIT; AU020960; PROTEASOME ACTIVATOR 28-GAMMA; 11S REGULATOR COMPLEX SUBUNIT GAMMA; PA28-GAMMA; ACTIVATOR OF MULTICATALYTIC PROTEASE SUBUNIT 3; PA28 GAMMA VARIANT 5; AA410043; PA28GAMMA; 11S REGULATOR COMPLEX GAMMA SUBUNIT; PROTEASOME ACTIVATOR 28 SUBUNIT GAMMA; PSME3; 3; REG-GAMMA; PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3; KI); RP23-281C18.14-001; PROTEASEOME (PROSOME
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Uniprot ID
P61289
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Gene Name
PSME3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PSME3 (P61289-1) (Met1-Tyr254) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PSME3 consists of 269 amino acids and predicts a molecular mass of 31.3 KDa. It migrates as an approximately 28-33 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human PSME3 / PA28-gamma Protein (His Tag) SDS-PAGE
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