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Product Name
Human Prostasin/PRSS8 (His Tag) recombinant protein
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Description
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
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Protein name
Prostasin
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Protein short names
FR; C79772; CAP1; 2410039E18RIK; PRSS8; MCAP1; PROSTASIN; AI313909; MCAP12410039E18RIK
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Uniprot ID
Q16651
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Gene Name
PRSS8
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human Prss8 (NP_002764.1) (Ala 30-Arg 322) was fused with a signal peptide at the N-terminus and a polyhistidine-tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The mature recombinant human Prss8 consists of 304 amino acids and predicts a molecular mass of 32.8 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhPrss8 is approximately 40 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC (R&D Systems, Catalog # ES014). The specific activity is >10 pmoles/min/μg.
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Validations
Human Prostasin / Prss8 Protein (His Tag) SDS-PAGE
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