Anti-Prostasin/PRSS8 antibody

Anti-Prostasin/PRSS8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to Prostasin/PRSS8

WB

Human Prostasin / PRSS8

CAP1 antibody; PROSTASIN antibody; fr antibody; CAP1 antibody; mCAP1 antibody; C79772 antibody; AI313909 antibody; 2410039E18Rik antibody; AI313909 antibody; C79772 antibody; CAP1 antibody; CAP1 antibody; mCAP12410039E18Rik antibody; Prostasin antibody; PROSTASIN antibody; Prss8 antibody; PRSS8 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human Prostasin / PRSS8 (rh Prostasin / PRSS8; NP_002764.1; Ala30-Arg322).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.