PPP1R9B antibody

PPP1R9B antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PPP1R9B Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, mouse spleen tissue, rat brain tissue. Observed molecular weight by Western-blot: 120kd

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

FLJ30345 antibody; Neurabin 2 antibody; Neurabin II antibody; PPP1R6 antibody; PPP1R9 antibody; PPP1R9B antibody; SPINO antibody; Spinophilin antibody; Spn antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_032595). Purification method: Antigen affinity purified.

Polyclonal

0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PPP1R9B, also named as PPP1R6, Neurabin-II and Spinophilin, seems to act as a scaffold protein in multiple signaling pathways. It modulates excitatory synaptic transmission and dendritic spine morphology. PPP1R9B binds to actin filaments (F-actin) and shows cross-linking activity. It may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. PPP1R9B plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. It may establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. PPP1R9B probably regulates p70 S6 kinase activity by forming a complex with TIAM. The antibody is specific to PPP1R9B.

• Wang C, Niu R, Zhu Y. Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A. Toxicology. 322:51-60. 2014.