PMS2 antibody

PMS2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PMS2 Mouse Monoclonal antibody. Positive WB detected in A431 cells, HeLa cells. Positive IHC detected in human cervical cancer tissue. Observed molecular weight by Western-blot: 100kd

ELISA, WB, IHC

Human; other species not tested.

HNPCC4 antibody; PMS1 protein homolog 2 antibody; PMS2 antibody; PMS2CL antibody; PMSL2 antibody

Mouse IgG2a

This antibody was obtained by immunization of PMS2 recombinant protein (Accession Number: NM_000535). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).