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Product Name
Rat PAI-1 / SerpinE1 (Fc Tag) recombinant protein
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Description
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).
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Protein name
Plasminogen activator inhibitor 1
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Protein short names
SERPIN E1; PLANH1 SERPIN E1; PAI-1; PLANH1; PAI; SERPINE1; PAI1
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Uniprot ID
P20961
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Gene Name
Serpine1; Pai1; Planh1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat SERPINE1 (NP_036752.1) (Met1-Pro402) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat SERPINE1 comprises 620 amino acids and has a predicted molecular mass of 69.6 kDa. The apparent molecular mass of the protein is approximately 70 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit uPA cleavage of a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The IC50 value is < 10 nM.
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Validations
Rat SerpinE1 / PAI-1 Protein (Fc Tag) SDS-PAGE
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