Pinin antibody

Pinin antibody

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• Material Safety Data Sheets (MSDS)

Pinin Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HepG2 cells, HT-1080 cells. Positive IP detected in HeLa cells. Positive IHC detected in human kidney tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 82 kDa,140 kDa

ELISA, IHC, IF, WB, IP

Human; other species not tested.

Desmosome assOCiated protein antibody; Domain rich serine protein antibody; DRS antibody; DRS protein antibody; DRSP antibody; memA antibody; Nuclear protein SDK3 antibody; Pinin antibody; PNN antibody; SDK3 antibody; SR like protein antibody

Rabbit IgG

This antibody was obtained by immunization of Pinin recombinant protein (Accession Number: NM_002687). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PNN, also named as DRS or 140 kDa nuclear and cell adhesion-related phosphoprotein, is a 717 amino acid protein, which belongs to the pinin family. PNN localizes in the plasma membrane and is expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. PNN is expressed strongly in melanoma metastasis lesions and advanced primary tumors. PNN as a transcriptional activator binds to the E-box 1 core sequence of the E-cadherin promoter gene. PNN is involved in the establishment and maintenance of epithelia cell-cell adhesion. PNN is a potential tumor suppressor for renal cell carcinoma. The calculated molecular weight of PNN is 82 kDa (native form), but the post-modified protein is 140 kDa (phospho form of isoform 1).