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Human PMVK / phosphomevalonate kinase (His Tag) recombinant protein

Cat.#: 501718

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Product Information

  • Product Name
    Human PMVK / phosphomevalonate kinase (His Tag) recombinant protein
  • Documents
  • Description
    PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
  • Protein name
    Phosphomevalonate kinase
  • Protein short names
    1110011E12RIK; PMKASE; PMVK; PMK; PHOSPHOMEVALONATE KINASE; HUMPMKI; 2900002L22RIK; AV001327; PMKA
  • Uniprot ID
    Q15126
  • Gene Name
    PMVK; PMKI
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human PMVK(Q15126) (Met1-Leu192) was expressed with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PMVK consists of 207 amino acids and predicts a molecular mass of 23.8 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human PMVK / phosphomevalonate kinase Protein (His Tag) SDS-PAGE

    Human PMVK / phosphomevalonate kinase Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"