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  • Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 pAb

Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 pAb

Cat.#: 166383

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Product Information

  • Product Name
    Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220
  • Tested applications
    WB, IHC
  • Species reactivity
    Human
  • Alternative names
    antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding S246 of human HDAC4
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IHC 1:50 - 1:100
  • Validations

    Western blot - Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 pAb

    Western blot - Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 pAb

    Western blot analysis of extracts from 293 cells untreated or treated with EGF using Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"