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Phospho-Estrogen Receptor beta-S105 pAb

Cat.#: 166504

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Product Information

  • Product Name
    Phospho-Estrogen Receptor beta-S105 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-Estrogen Receptor beta-S105
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    ESR2 antibody; ER-BETA antibody; ESR-BETA antibody; ESRB antibody; ESTRB antibody; Erb antibody; NR3A2 antibody; estrogen receptor 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding S105 of human Estrogen Receptor beta
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
  • Validations

    Western blot - Phospho-Estrogen Receptor beta-S105 pAb

    Western blot - Phospho-Estrogen Receptor beta-S105 pAb

    Western blot analysis of extracts of HepG2 cells, using Phospho-Estrogen Receptor beta-S105 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"