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Periostin antibody

Cat.#: 113715

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Product Information

  • Product Name
    Periostin antibody
  • Documents
  • Description
    Periostin Rabbit Polyclonal antibody. Positive WB detected in BxPC-3 cells, mouse lung tissue, SGC-7901 cells. Positive IHC detected in human colon tissue, human breast cancer tissue. Observed molecular weight by Western-blot: 85-90 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    OSF 2 antibody; OSF2 antibody; Osteoblast specific factor 2 antibody; PDLPOSTN antibody; Periostin antibody; POSTN antibody; RP11 412K4.1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Periostin recombinant protein (Accession Number: NM_001135934). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:50-1:500

  • Validations

    BxPC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:113715(POSTN antibody) at dilution of 1:500

    BxPC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:113715(POSTN antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:113715(POSTN Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:113715(POSTN Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:113715(POSTN Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:113715(POSTN Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    Periostin (POSTN, PN), originally named as osteoblast-specific factor 2 (OSF-2), is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues, and has a role in bone, tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types, includidng lung, ovary, breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour, and it is required to allow cancer stem cell maintenance.
  • References
    • Chen SX, Xu XE, Wang XQ. Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation. Journal of proteomics. 110:155-71. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"