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Product Name
Human FKBP12/FKBP1A (His Tag) recombinant protein
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Description
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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Protein name
Peptidyl-prolyl cis-trans isomerase FKBP1A
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Protein short names
RP11-314N13.2; FKBP12-T1; MFKBP12; FKBP; PKCI2; FKBP1A; FKBP12-T2; FKBP12; FKBP-12; FKBP1; PKC12; MFKBP1; RP23-419G21.5; FKBP-1A; PPIASE; FKBP12C
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Uniprot ID
P62942
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Gene Name
FKBP1A; FKBP1; FKBP12
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human FKBP12 (NP_463460) (Met 1-Glu 108) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The recombinant human FKBP12 consists of 114 amino acids and predicts a molecular mass of 12.9 kDa as estimated by SDS-PAGE.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human FKBP12 Protein (His Tag) SDS-PAGE
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