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Product Name
PDRG1 antibody
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Description
PDRG1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Positive IF detected in HepG2 cells. Positive IHC detected in human kidney tissue, human liver tissue. Observed molecular weight by Western-blot: 16 kDa
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
C20orf126 antibody; p53 and DNA damage regulated 1 antibody; PDRG antibody; PDRG1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PDRG1 recombinant protein (Accession Number: NM_030815). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:113636(PDRG1 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human kidney using Catalog No:113636(PDRG1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:113636(PDRG1 antibody) at dilution of 1:100 (under 40x lens)
Immunofluorescent analysis of HepG2 cells, using PDRG1 antibody Catalog No:113636 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
PDRG1 codes for a novel protein called p53 and DNA damage-regulated protein 1. Human PDRG1 is predominantly expressed in normal testis and its expression can be induced by UV irradiation and be repressed by p53 [PMID14562055]. Recently, PDRG1 was identified as a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress. Its expression was upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus when compared to normal tissues [PMID: 21193842], suggesting its being a novel tumor marker that could play a role in cancer development and/or progression.
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