PAWR antibody

PAWR antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PAWR Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue, mouse kidney tissue. Positive IHC detected in human breast cancer tissue, human kidney tissue. Observed molecular weight by Western-blot: 45kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

Par 4 antibody; PAR4 antibody; PAWR antibody; Prostate apoptosis response 4 protein antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_002583). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PAWR, also named as PAR4, is a pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. It induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. PAWR inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. It down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. PAWR may be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. The antibody is specific to PAWR.