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Product Name
PALMD antibody
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Description
PALMD Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive IP detected in mouse heart tissue,. Positive WB detected in HeLa cells, mouse lung tissue. Observed molecular weight by Western-blot: 80 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
C1orf11 antibody; FLJ20271 antibody; PALMD antibody; palmdelphin antibody; PALML antibody; Paralemnin like protein antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PALMD recombinant protein (Accession Number: NM_017734). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113564(PALMD antibody) at dilution of 1:300
IP Result of anti-PALMD (IP:Catalog No:113564, 5ug; Detection:Catalog No:113564 1:500) with mouse heart tissue lysate 6000ug.
IP result of PALMD antibody (Catalog No:113564 for Ip and Detection) with mouse heart tissue lysate.
Immunohistochemical of paraffin-embedded human liver using Catalog No:113564(PALMD antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:113564(PALMD antibody) at dilution of 1:100 (under 40x lens)
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Background
Palmdelphin, encoded by PALMD gene, is a newly identified cytosolic isoform of paralemmin-1, a lipid raft-associated protein implicated in cell shape control. Paralemmin (Palm) is a prenyl-palmitoyl anchored membrane protein that can drive membrane and process formation in neurons. Previous finding suggest that palmdelphin may peripherally associate with endomembranes or cytoskeleton-linked structures. Palmdelphin appears to be 80 kDa in Western blotting, larger than the predicated of 63 kDa, and this may be due to the acidic nature of this protein or its posttranslational modification.
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References
- Dashzeveg N, Taira N, Lu ZG, Kimura J, Yoshida K. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell death & disease. 5:e1221. 2014.
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