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Product Name
ORM2 antibody
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Description
ORM2 Rabbit Polyclonal antibody. Positive IP detected in L02 cells. Positive WB detected in A549 cells, L02 cells, mouse liver tissue. Positive IHC detected in human prostate cancer tissue. Positive IF detected in Hela cells. Observed molecular weight by Western-blot: 24-28 kDa
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Tested applications
ELISA, WB, IHC, IF, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
AGP 2 antibody; AGP B antibody; AGP B' antibody; AGP2 antibody; Alpha 1 acid glycoprotein 2 antibody; OMD 2 antibody; ORM2 antibody; orosomucoid 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ORM2 recombinant protein (Accession Number: NM_000608). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:113426(ORM2 antibody) at dilution of 1:800
IP Result of anti-ORM2 (IP:Catalog No:113426, 3ug; Detection:Catalog No:113426 1:800) with L02 cells lysate 2500ug.
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:113426(ORM2 antibody) at dilution of 1:50 (under 10x lens)
Immunofluorescent analysis of Hela cells, using ORM2 antibody Catalog No:113426 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
ORM2, also named as AGP2 and OMD 2, belongs to the calycin superfamily and Lipocalin family. It functions as transport protein in the blood stream. ORM2 binds various hydrophobic ligands in the interior of its beta-barrel domain. It also binds synthetic drugs and influences their distribution and availability. ORM2 appears to function in modulating the activity of the immune system during the acute-phase reaction. ORM2 is one of the conserved endoplasmic reticulum membrane proteins which regulating lipid homeostasis and protein quality control. This antibody can recognize both ORM1 and ORM2.
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References
- Kang UB, Ahn Y, Lee JW. Differential profiling of breast cancer plasma proteome by isotope-coded affinity tagging method reveals biotinidase as a breast cancer biomarker. BMC cancer. 10:114. 2010.
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