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Product Name
NUS1 antibody
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Description
NUS1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, mouse pancreas tissue. Observed molecular weight by Western-blot: 30-33 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
C6orf68 antibody; NgBR antibody; Nogo B receptor antibody; NUS1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of NUS1 recombinant protein (Accession Number: NM_138459). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113447(NUS1 Antibody) at dilution of 1:800
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Background
Nogo proteins containing three isoforms (Nogo A,B,C) have been implicated in a variety of critical cellular processes including CNS neuronal regeneration, vascular cell spreading and chemotaxis. While only two functional receptors have been reported so far: NgR binding all three Nogos and NgBR specifically binding Nogo-B. Nogo-B receptor, also known as NgBR or NUS1, specifically binds the amino amino terminus (residues 1-200) of Nogo-B, the interaction of which is essential for stimulating chemotaxis, morphogenesis and angiogenesis.Western blot analysis detected high NgBR expression in mouse heart, liver, kidney, and pancreas with molecular weight around 30-33 kD.
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References
- Eckharter C, Junker N, Winter L. Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR. Frontiers in cellular neuroscience. 9:454. 2015.
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