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Product Name
Anti-Nogo B receptor Rabbit antibody
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Description
Nogo B receptor Rabbit polyclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
NgBR; MRD55; CDG1AA; C6orf68; TANGO14; MGC:7199 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Nogo B receptor
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
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Validations
Western blot detection of Nogo B receptor in K562,3T3,Hela cell lysates using Nogo B receptor Rabbit pAb(1:1000 diluted).Predicted band size:33kDa.Observed band size:33kDa.
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Background
Swiss-Prot Acc.Q96E22.With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"