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Product Name
NUR77 antibody
- Documents
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Description
NUR77 Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 70-80 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Early response protein NAK1 antibody; GFRP1 antibody; HMR antibody; N10 antibody; NAK 1 antibody; NAK1 antibody; NGFIB antibody; NR4A1 antibody; NUR77 antibody; Orphan nuclear receptor HMR antibody; Orphan nuclear receptor TR3 antibody; ST 59 antibody; Testicular receptor 3 antibody; TR3 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of NUR77 recombinant protein (Accession Number: NM_002135). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:113445(NR4A1 antibody) at dilution of 1:100
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Background
NR4A1 is an orphan nuclear receptor that act concomitantly with NURR1 in regulating the expression of delay-early genes during liver regeneration. Also NR4A1 has linked not only to cell apoptosis but also proliferation in response to growth factor. It plays a role in caspase-independent cell death by activation of the ERK pathway and increased activity of MEF2 transcription factors.
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References
- Yu C, Cui S, Zong C. The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis. The Journal of biological chemistry. 290(34):20687-99. 2015.
- Wei X, Gao H, Zou J. Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment. Molecular neurobiology. 2015.
- Yang B, Yu D, Liu J, Yang K, Wu G, Liu H. Antitumor activity of SAHA, a novel histone deacetylase inhibitor, against murine B cell lymphoma A20 cells in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(7):5051-61. 2015.
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