NR5A1 antibody

NR5A1 antibody

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NR5A1 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human ovary tissue. Positive WB detected in mouse ovary tissue. Positive IP detected in A2780 cells. Observed molecular weight by Western-blot: 53 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

AD4BP antibody; Adrenal 4 binding protein antibody; ELP antibody; FTZ1 antibody; FTZF1 antibody; Fushi tarazu factor homolog 1 antibody; NR5A1 antibody; SF 1 antibody; SF1 antibody; SF-1 antibody; Steroid hormone receptor Ad4BP antibody; Steroidogenic factor 1 antibody; STF 1 antibody

Rabbit IgG

This antibody was obtained by immunization of NR5A1 recombinant protein (Accession Number: NM_004959). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Steroidogenic factor-1 (SF-1,STF-1), also known as NR5A1, regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. Initially identified as a tissue-specific transcriptional regulator of cytochrome P450 steroid hydroxylases, research studies of both global and tissue-specific knockout mice have demonstrated that SF-1 is required for the development of adrenal glands, gonads, ventromedial hypothalamus, and for the proper functioning of pituitary gonadotropes. Indeed, humans with mutations that render SF-1 transcriptionally inactive can present with testicular failure, ovarian failure, and adrenal insufficiency. Furthermore, dysregulation of SF-1 has been linked to diseases such as endometriosis and adrenocortical carcinoma.Like other nuclear hormone receptors, SF-1 has a modular domain structure composed of an N-terminal zinc finger DNA-binding domain, a ligand-binding domain, a C-terminal AF-2 activation domain, and a hinge region with AF-1-like activation activity. SF-1 also contains a fushi tarazu factor 1 box, which functions as an accessory DNA binding domain. SF-1 is primarily phosphorylated at Ser203, which is thought to enhance its transcriptional activity by promoting complex formation with transcriptional cofactors. In addition to phosphorylation at Ser203, SF-1 is subject to SUMO conjugation and acetylation at ε-amino groups of target lysine residues. Whereas SUMOylation represses SF-1 function, acetylation enhances its transcriptional activity.In the adult ovary, SF-1 localizes to theca/interstitial cells.