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NR1H3 antibody

Cat.#: 113232

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Special Price 239.0 USD

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Product Information

  • Product Name
    NR1H3 antibody
  • Documents
  • Description
    NR1H3 Rabbit Polyclonal antibody. Positive WB detected in Sp2/0 cells, rat colon tissue. Observed molecular weight by Western-blot: 44-48 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Liver X receptor alpha antibody; LXR a antibody; LXRA antibody; NR1H3 antibody; Oxysterols receptor LXR alpha antibody; RLD 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of NR1H3 recombinant protein (Accession Number: XM_047426198). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

  • Validations

    Sp2/0 cells were subjected to SDS PAGE followed by western blot with Catalog No:113232(NR1H3 antibody) at dilution of 1:800

    Sp2/0 cells were subjected to SDS PAGE followed by western blot with Catalog No:113232(NR1H3 antibody) at dilution of 1:800

  • Background
    NR1H3, also known as LXRA, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It's also a ligand-activated LXRs and forms heterodimers with retinoid X receptor, then participates in regulating expression of target genes containing LXR response elements.
  • References
    • Ma X, Wang Q, Liu Y. Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production. International journal of cancer. 136(4):771-83. 2015.
    • Hu YW, Ma X, Huang JL. Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet. PloS one. 8(6):e66876. 2013.
    • Wang Q, Ma X, Chen Y. Identification of interferon-γ as a new molecular target of liver X receptor. The Biochemical journal. 459(2):345-54. 2014.
    • Zhao JY, Hu YW, Li SF. Dihydrocapsaicin down-regulates apoM expression through inhibiting Foxa2 expression and enhancing LXRα expression in HepG2 cells. Lipids in health and disease. 13:50. 2014.
    • Wang S, Xiaoling G, Pingting L, Shuqiang L, Yuaner Z. Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats. Lipids in health and disease. 13:77. 2014.
    • Hu YW, Yang JY, Ma X. A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis. Journal of lipid research. 55(4):681-97. 2014.
    • Zhang L, Jiang M, Shui Y. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochimica et biophysica acta. 1831(6):1134-45. 2013.
    • Luu W, Sharpe LJ, Brown AJ. Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression. Atherosclerosis. 228(2):362-9. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"