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Product Name
NR1H3 antibody
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Description
NR1H3 Mouse Monoclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in MCF7 cells, HepG2 cells. Observed molecular weight by Western-blot: 50 kDa 44 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human, Rat; other species not tested.
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Alternative names
Liver X receptor alpha antibody; LXR a antibody; LXRA antibody; NR1H3 antibody; Oxysterols receptor LXR alpha antibody; RLD 1 antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of NR1H3 recombinant protein (Accession Number: XM_047426198). Purification method: Caprylic acid/ammonium sulfate precipitation.
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IF: 1:10-1:100
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107336(NR1H3 antibody) at dilution of 1:300
Immunofluorescent analysis of HepG2 cells using Catalog No:107336(NR1H3 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)
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Background
NR1H3, also known as LXRA, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation.. It's also a ligand-activated LXRs and forms heterodimers with retinoid X receptor, then participates in regulating expression of target genes containing LXR response elements.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"