NOTCH3 Polyclonal Antibody

Cat.#: 161669

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Product Information

  • Product Name
    NOTCH3 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to NOTCH3
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    NOTCH3 antibody; CADASIL antibody; CADASIL1 antibody; CASIL antibody; IMF2 antibody; LMNS antibody; notch 3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide corresponding to a sequence within amino acids 2200 to the C-terminus of human NOTCH3 (NP_000426.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
  • Validations

    Western blot - NOTCH3 Polyclonal Antibody

    Western blot - NOTCH3 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using NOTCH3 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 5s.

  • Background
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"