NKD2 Rabbit Polyclonal antibody. Positive WB detected in mouse kidney tissue, HEK-293 cells, mouse colon tissue. Observed molecular weight by Western-blot: 59kd
Human,Mouse,Rat; other species not tested.
hNkd2 antibody; Naked 2 antibody; Naked2 antibody; NKD2 antibody
This antibody was obtained by immunization of NKD2 recombinant protein (Accession Number: BC012176). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
mouse kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:113196(Naked2 antibody) at dilution of 1:400
Naked2 (protein naked cuticle homolog 2), encoded by NKD2 gene, was identified as a cell autonomous antagonist of the canonical Wnt signaling pathway. Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells (PMID: 17553928). EGFR-independent action of TGF-alpha protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface (PMID: 18757723). Myristoylated Naked2 antagonizes Wnt-beta-catenin activity possibly by degrading Dishevelled-1 at the plasma membrane (PMID: 20177058).
- Zhao S, Kurenbekova L, Gao Y. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 34(39):5069-79. 2015.
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