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Product Name
Human DCX (aa 45-150, GST Tag) recombinant protein
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Description
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
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Protein name
Neuronal migration protein doublecortin
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Protein short names
DBCT; X-LINKED (DOUBLECORTIN); LISSENCEPHALY; DBCN; SCLH; DOUBLING; LISX; NEURONAL MIGRATION PROTEIN DOUBLECORTIN; XLIS; LIS-X; LISSENCEPHALIN-X; DOUBLECORTEX; DC
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Uniprot ID
O43602
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Gene Name
DCX; DBCN; LISX
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human DCX (O43602-2) N-terminal fragment (Ala 45-Val 150) was fused with the GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human DCX (aa 45-150)/GST chimera consists of 340 amino acids and has a predicted molecular mass of 39.4 kDa. It migrates as an approxiamtely 36 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 82 % as determined by SDS-PAGE
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Validations
Human DCX Protein (aa 45-150, GST Tag) SDS-PAGE
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