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Product Name
Human UNC5B / UNC5H2 (His Tag) recombinant protein
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Description
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
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Protein name
Netrin receptor UNC5B
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Protein short names
P53RDL1; UNC5H2; UNC5B; TRANSMEMBRANE RECEPTOR UNC5H2; P53-REGULATED RECEPTOR FOR DEATH AND LIFE PROTEIN 1; UNC5 HOMOLOG 2; 6330415E02RIK; UNC-5 HOMOLOG 2; RP11-58O1.1; UNC-5 HOMOLOG B (C. ELEGANS); PROTEIN UNC-5 HOMOLOG 2; NETRIN RECEPTOR UNC5B; A630020F16; PROTEIN UNC-5 HOMOLOG B; D10BWG0792E
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Uniprot ID
Q8IZJ1
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Gene Name
UNC5B; P53RDL1; UNC5H2; UNQ1883/PRO4326
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human UNC5B (NP_734465.2) (Met1-Pro363) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human UNC5B consists 348 amino acids and predicts a molecular mass of 39.2 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human UNC5B / UNC5H2 Protein (His Tag)
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