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  • Human SETD8/PR-Set7 recombinant protein

Human SETD8/PR-Set7 recombinant protein

Cat.#: 500218

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Product Information

  • Product Name
    Human SETD8/PR-Set7 recombinant protein
  • Documents
  • Description
    Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
  • Protein name
    N-lysine methyltransferase SETD8
  • Protein short names
    2410195B05RIK; MGC117832; AA617402; PR-SET7; SET07; AW536475; KMT5A; SETD8; SET8
  • Uniprot ID
    Q9NQR1
  • Gene Name
    SETD8; KMT5A; PRSET7; SET07; SET8
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SETD8 (NP_065115.3) (Lys 195-His 352) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human SETD8 comprises 160 amino acids and has a predicted molecular mass of 18.2 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Validations

    Human SETD8 / PR-Set7 Protein SDS-PAGE

    Human SETD8 / PR-Set7 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"