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MZB1 antibody

Cat.#: 113006

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Product Information

  • Product Name
    MZB1 antibody
  • Documents
  • Description
    MZB1 Rabbit Polyclonal antibody. Positive WB detected in Raji cells. Positive IHC detected in human gliomas tissue, human small intestine tissue. Observed molecular weight by Western-blot: 19-21 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    FLJ32987 antibody; hypothetical protein MGC29506 antibody; MZB1 antibody; PACAP antibody; pERp1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MZB1 recombinant protein (Accession Number: NM_016459). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:113006(MZB1 antibody) at dilution of 1:1000

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:113006(MZB1 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:113006(MZB1 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:113006(MZB1 antibody) at dilution of 1:50 (under 40x lens)

  • Background
    MZB1, also named as ,PACAP, MGC29506 and pERp1, belongs to the PERP1 family. It is associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. MGC29506(PACAP) may exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. (PubMed: 11350957) MZB1 has 5 isoforms with MW 21kd and 7-13kd.
  • References
    • Matsumura S, Imoto I, Kozaki K. Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 18(13):3541-51. 2012.
    • Belkaya S, Murray SE, Eitson JL, de la Morena MT, Forman JA, van Oers NS. Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1. The Journal of biological chemistry. 288(42):30752-62. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"