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  • MVP/LRP antibody
  • MVP/LRP antibody
  • MVP/LRP antibody
  • MVP/LRP antibody

MVP/LRP antibody

Cat.#: 112907

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Product Information

  • Product Name
    MVP/LRP antibody
  • Documents
  • Description
    MVP/LRP Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human lung tissue, human breast cancer tissue, human kidney tissue, human liver tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue. Positive IP detected in mouse lung tissue. Positive WB detected in SH-SY5Y cells, A549 cells, HEK-293 cells, human brain tissue, mouse lung tissue, rat lung tissue, RAW264.7 cells. Observed molecular weight by Western-blot: 100-104kd
  • Tested applications
    ELISA, WB, IHC, IF, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    LRP antibody; major vault protein antibody; MVP antibody; VAULT1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MVP/LRP recombinant protein (Accession Number: BC015623). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • Validations

    SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:112907(MVP antibody) at dilution of 1:500

    SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:112907(MVP antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human lung using Catalog No:112907(MVP antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lung using Catalog No:112907(MVP antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of HepG2 cells, using MVP antibody Catalog No:112907 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

    Immunofluorescent analysis of HepG2 cells, using MVP antibody Catalog No:112907 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

    IP Result of anti-MVP (IP:Catalog No:112907, 4ug; Detection:Catalog No:112907 1:500) with mouse lung tissue lysate 4000ug.

    IP Result of anti-MVP (IP:Catalog No:112907, 4ug; Detection:Catalog No:112907 1:500) with mouse lung tissue lysate 4000ug.

  • Background
    Vaults are the largest cellular ribonuclear protein complexes with a hollow barrel-like structure, and have been associated with the MDR phenotype. Major vault protein (MVP) is the main component of vaults and is presumed to be involved in MDR. MVP is identical with the human lung resistance protein (LRP), known to be overexpressed in multiple chemotherapy resistance models [PMID:23083532]. MVP has been associated to resistance to radiotherapy [4], probably due to its role in preventing apoptosis by inhibiting the COP-1/p53 axis [PMID: 12894554, 15994960].
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"