MVP/LRP Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human lung tissue, human breast cancer tissue, human kidney tissue, human liver tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue. Positive IP detected in mouse lung tissue. Positive WB detected in SH-SY5Y cells, A549 cells, HEK-293 cells, human brain tissue, mouse lung tissue, rat lung tissue, RAW264.7 cells. Observed molecular weight by Western-blot: 100-104kd
ELISA, WB, IHC, IF, IP
Human,Mouse,Rat; other species not tested.
LRP antibody; major vault protein antibody; MVP antibody; VAULT1 antibody
This antibody was obtained by immunization of MVP/LRP recombinant protein (Accession Number: BC015623). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:112907(MVP antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lung using Catalog No:112907(MVP antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of HepG2 cells, using MVP antibody Catalog No:112907 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
IP Result of anti-MVP (IP:Catalog No:112907, 4ug; Detection:Catalog No:112907 1:500) with mouse lung tissue lysate 4000ug.
Vaults are the largest cellular ribonuclear protein complexes with a hollow barrel-like structure, and have been associated with the MDR phenotype. Major vault protein (MVP) is the main component of vaults and is presumed to be involved in MDR. MVP is identical with the human lung resistance protein (LRP), known to be overexpressed in multiple chemotherapy resistance models [PMID:23083532]. MVP has been associated to resistance to radiotherapy , probably due to its role in preventing apoptosis by inhibiting the COP-1/p53 axis [PMID: 12894554, 15994960].
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