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MVD antibody

Cat.#: 112905

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Product Information

  • Product Name
    MVD antibody
  • Documents
  • Description
    MVD Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue, human heart tissue. Positive IF detected in A431 cells. Positive WB detected in A431 cells. Observed molecular weight by Western-blot: 66-74 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat; other species not tested.
  • Alternative names
    FP17780 antibody; MDDase antibody; MPD antibody; MVD antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MVD recombinant protein (Accession Number: NM_002461). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

    IF: 1:50-1:500

  • Validations

    A431 cells were subjected to SDS PAGE followed by western blot with Catalog No:112905(MVD antibody) at dilution of 1:800

    A431 cells were subjected to SDS PAGE followed by western blot with Catalog No:112905(MVD antibody) at dilution of 1:800

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:112905(MVD antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:112905(MVD antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:112905(MVD antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:112905(MVD antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of (10% Formaldehyde) fixed A431 cells using Catalog No:112905(MVD Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (10% Formaldehyde) fixed A431 cells using Catalog No:112905(MVD Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    The enzyme mevalonate pyrophosphate decarboxylase(MVD) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate. It is also named as MPD and as a unique enzyme in one of the early steps in cholesterol biosynthesis, MVD may be a useful target for drugs aimed at lowering serum cholesterol levels(PMID:8626466). The intracellular glycosylation does not contribute to the difference between the 45 and 37 kDa species of MVD. The native MVD has a molecular weight of 90 kDa that it consists of two identical subunits of 45 kDa and a 37 kDa protein is also found as a subunit of MVD and this type of MVD may be a 74 kDa.But the 37 kDa enzyme appeared only when the rats are fed the CP diet.(PMID:9348097).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"